Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma.

ABSTRACT:

Background and aim

Colorectal cancer (CRC) ranks the second most common cause of cancer-related mortality worldwide. Ferroptosis, a recently discovered form of programmed cell death different from other, raises promising novel opportunities for therapeutic intervention of CRC. This study intended to systematically assess the prognosis value and multiple roles of the ferroptosis-related genes in the tumor immune microenvironment of CRC.

Materials and methods

Of 1,192 CRC patients with complete information from the public datasets (TCGA CRC, GEO GSE39582 and GSE17538 cohorts) were selected for analysis. Firstly, K-means consensus clustering was performed to identify ferroptosis-associated subtypes in CRC patients. Subsequently, we constructed a risk signature based on ferropto

SUBMITTER: Yang C 

PROVIDER: S-EPMC8286063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature