Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC8286096 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yu Haiyang H Lu Shan S Gasior Kelsey K Singh Digvijay D Vazquez-Sanchez Sonia S Tapia Olga O Toprani Divek D Beccari Melinda S MS Yates John R JR Da Cruz Sandrine S Newby Jay M JM Lafarga Miguel M Gladfelter Amy S AS Villa Elizabeth E Cleveland Don W DW
Science (New York, N.Y.) 20201217 6529
The RNA binding protein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases. In this study, we found that RNA binding-deficient TDP-43 (produced by neurodegeneration-causing mutations or posttranslational acetylation in its RNA recognition motifs) drove TDP-43 demixing into intranuclear liquid spherical shells with liquid cores. These droplets, which we named "anisosomes", have shells that exhibit birefringence, thus indicating liquid crystal formation. ...[more]