Exploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats.

ABSTRACT:

Background

More and more burn survivors were suffering from varying degrees of damage to the intestinal barrier. Dexmedetomidine (Dex) was frequently used as sedative in more cases, but it was found to have repair effect on intestinal barrier dysfunction recently. This study aimed to explore the potential specific targets of Dex in intestinal barrier repair in burn rats model.

Methods

Male adult SD rats were used to establish 40% TBSA III degree scald model in our study. The samples were divided into four groups: burn rats (Burn), burn rats with Dex medication (Burn-Dex), sham rats (Sham) and sham rats with Dex medication (Sham-Dex). And plasma FITC-dextran and diamine oxidase (DAO) were detected to determine the intestinal permeability. Differentially expressed proteins wer

SUBMITTER: Qin C 

PROVIDER: S-EPMC8286122 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature