ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

ABSTRACT:

Backgroud & aims

Gastric cancer (GC) is the third leading cause of global cancer mortality. Adenosine-to-inosine RNA editing is a recently described novel epigenetic mechanism involving sequence alterations at the RNA but not DNA level, primarily mediated by ADAR (adenosine deaminase that act on RNA) enzymes. Emerging evidence suggests a role for RNA editing and ADARs in cancer, however, the relationship between RNA editing and GC development and progression remains unknown.

Methods

In this study, we leveraged on the next-generation sequencing transcriptomics to demarcate the GC RNA editing landscape and the role of ADARs in this deadly malignancy.

Results

Relative to normal gastric tissues, almost all GCs displayed a clear RNA misediting phenotype with ADAR1/2 dysreg

SUBMITTER: Chan TH 

PROVIDER: S-EPMC8286172 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature