Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.

ABSTRACT:

Objective

We examined whether sarcopenia is associated with the occurrence of late-life cognitive impairment.

Methods

Nondemented older adults (N = 1175) underwent annual testing with 17 cognitive tests summarized as a global cognitive score. A composite sarcopenia score was constructed based on muscle mass measured with bioelectrical impedance and muscle function based on grip strength. Cox proportional hazard models were employed to examine associations of sarcopenia with incident Alzheimer's dementia (AD) and incident mild cognitive impairment (MCI). Linear mixed-effect models determined the association of sarcopenia with cognitive decline. All models controlled for age, sex, education, race, and height squared.

Results

Average follow-up was 5.6 years. More severe

SUBMITTER: Beeri MS 

PROVIDER: S-EPMC8286176 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature