Standardisation of conventional and advanced iterative reconstruction methods for Gallium-68 multi-centre PET-CT trials.

ABSTRACT:

Purpose

To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisation, OSEM) and advanced iterative reconstructions which include the systems' point spread function (PSF) and a Bayesian penalised likelihood algorithm (BPL) commercially known as Q.CLEAR. The possibility of standardising the two advanced reconstruction methods was examined.

Methods

The NEMA image quality phantom was filled with Gallium-68 and scanned on a GE PET-CT system. PSF and BPL with varying post-reconstruction Gaussian filter width (2-6.4 mm) and penalisation factor (200-1200), respectively, were applied. The average peak-to-valley ratio from six profiles

SUBMITTER: Krokos G 

PROVIDER: S-EPMC8286213 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature