Multiblock Discriminant Analysis of Integrative ¹⁸F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy.

ABSTRACT:

Purpose

The main objective of the present study was to integrate ¹⁸F-FDG-PET/CT radiomics with multiblock discriminant analysis for predicting circulating tumor cells (CTCs) in early-stage non-small cell lung cancer (ES-NSCLC) treated with stereotactic body radiation therapy (SBRT).

Methods

Fifty-six patients with stage I NSCLC treated with SBRT underwent ¹⁸F-FDG-PET/CT imaging pre-SBRT and post-SBRT (median, 5 months; range, 3-10 months). CTCs were assessed via a telomerase-based assay before and within 3 months after SBRT and dichotomized at 5 and 1.3 CTCs/mL. Pre-SBRT, post-SBRT, and delta PET/CT radiomics features (n = 1548 × 3/1562 × 3) were extracted from gross tumor volume. Seven feature blocks were constructed including clinical parameters (n =

SUBMITTER: Lee SH 

PROVIDER: S-EPMC8286285 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature