Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells.

ABSTRACT: Outcomes for triple negative breast cancer (TNBC) are poor and may be improved by increasing CD8⁺ tumor infiltrating lymphocytes (TIL) to augment antitumor immunity. Radiation (RT) can promote immunogenic cell death with increased antitumor T cell activity but also stimulates suppressive regulatory T cells (Tregs). Because metabolic alterations affect immune homeostasis and prior studies show caloric restriction (CR) combined with RT improves preclinical TNBC outcomes, we hypothesized that CR augments RT, in part, by altering intratumoral immunity. Using an in vivo model of TNBC, we treated mice with ad libitum (AL) diet, radiation, a CR diet, or CR + RT, and demonstrated an immune suppressive environment with a significant increase in CD4⁺ CD25⁺Foxp3⁺

SUBMITTER: Manukian G 

PROVIDER: S-EPMC8286289 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature