HIV, hepatitis C virus and risk of new-onset left ventricular dysfunction in women.

ABSTRACT:

Background

HIV and HCV have each been linked with cardiac dysfunction. Studies of HIV have often lacked appropriate controls and primarily involved men, whereas data for HCV are sparse.

Methods

We performed repeat echocardiography over a median interval of 12 years in participants from the Women's Interagency HIV Study in order to evaluate the relationships of HIV and HCV with incident left ventricular (LV) dysfunction (systolic or diastolic).

Results

Of the 311 women included (age 39 ± 9), 70% were HIV-positive and 20% HCV-positive. Forty three participants (13.8%) developed LV dysfunction, of which 79.1% was diastolic. Compared with participants with neither infection, the group with HIV--HCV coinfection showed a significantly increased risk of incident LV dysfuncti

SUBMITTER: Shitole SG 

PROVIDER: S-EPMC8286303 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature