Movement-related changes in pallidocortical synchrony differentiate action execution and observation in humans.

ABSTRACT:

Objective

Suppression of local and network alpha and beta oscillations in the human basal ganglia-thalamocortical (BGTC) circuit is a prominent feature of movement, including suppression of local alpha/beta power, cross-region beta phase coupling, and cortical and subcortical phase-amplitude coupling (PAC). We hypothesized that network-level coupling is more directly related to movement execution than local power changes, given the role of pathological network hypersynchrony in movement disorders such as Parkinson disease (PD). Understanding the specificity of these movement-related signals is important for designing novel therapeutics.

Methods

We recorded globus pallidus internus (GPi) and motor cortical local field potentials during movement execution, passive movement obs

SUBMITTER: Cross KA 

PROVIDER: S-EPMC8286311 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature