Changes in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT.

ABSTRACT:

Purpose

Hypertension is a risk factor for cognitive impairment; however, the mechanisms leading to cognitive changes remain unclear. In this cross-sectional study, we evaluate the impact of white matter lesion (WML) burden on brain functional connectivity (FC) and cognition in a large cohort of hypertensive patients from the Systolic Blood Pressure Intervention Trial (SPRINT) at baseline.

Methods

Functional networks were identified from baseline resting state functional MRI scans of 660 SPRINT participants using independent component analysis. WML volumes were calculated from structural MRI. Correlation analyses were carried out between mean FC of each functional network and global WML as well as WML within atlas-defined white matter regions. For networks of interest, voxel-

SUBMITTER: Shah C 

PROVIDER: S-EPMC8286444 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature