Neuroprotective Effects of Isoquercetin: An In Vitro and In Vivo Study.

ABSTRACT:

Objective

Alzheimer's disease (AD) is considered a neurodegenerative disease that affects the cognitive function of elderly individuals. In this study, we aimed to analyze the neuroprotective potential of isoquercetin against the in vitro and in vivo models of AD and investigated the possible underlying mechanisms.

Materials and methods

The experimental study was performed on PC12 cells treated with lipopolysaccharide (LPS). Reactive oxygen species (ROS), antioxidant parameters, and pro-inflammatory cytokines were measured. In an in vivo approach, Wistar rats were used and divided into different groups. We carried out the Morris water test to determine the cognitive function. Biochemical parameters, antioxidant parameters, and pro-inflammatory parameters

SUBMITTER: Yang Q 

PROVIDER: S-EPMC8286454 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature