High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.

ABSTRACT: Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to immune checkpoint blockade ¹, this has not been comprehensively evaluated in large randomized studies. Here we analyzed circulating pIL-8 and IL8 gene expression in peripheral blood mononuclear cells and tumors of patients treated with atezolizumab (anti-PD-L1 monoclonal antibody) from multiple randomized trials representing 1,445 patients with metastatic urothelial carcinoma (mUC) and metastatic renal cell carcinoma. High levels of IL-8 in plasma, peripheral blood mononuclear cells and tumors were associated with decreased efficacy of atezolizumab in patients with mUC and metastatic renal cell carcinoma, even in tumors that were classically CD8⁺ T cell inflamed. Low baseline pIL-8

SUBMITTER: Yuen KC 

PROVIDER: S-EPMC8286544 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature