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Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient.

ABSTRACT: Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.

SUBMITTER: Alshukairi AN

PROVIDER: S-EPMC8286546 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient.

Alshukairi Abeer N AN El-Kafrawy Sherif A SA Dada Ashraf A Yasir Muhammad M Yamani Amani H AH Saeedi Mohammed F MF Aljohaney Ahmed A AlJohani Naif I NI Bahaudden Husam A HA Alam Intikhab I Gojobori Takashi T Radovanovic Aleksandar A Alandijany Thamir A TA Othman Norah A NA Alsubhi Tagreed L TL Hassan Ahmed M AM Tolah Ahmed M AM Al-Tawfiq Jaffar A JA Zumla Alimuddin A Azhar Esam I EI

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20210718

Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed. ...[more]

PMID: 34289407

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