Biomimetic recombinant of red blood cell membranes for improved photothermal therapy.

ABSTRACT:

Background

RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function.

Results

In this study, we reported a green technology of "disassembly-reassembly" to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the pro

SUBMITTER: Wu P 

PROVIDER: S-EPMC8286575 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature