Association between cervical dysplasia and female genital schistosomiasis diagnosed by genital PCR in Zambian women.

ABSTRACT:

Background

Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS is caused by Schistosoma haematobium, a parasitic carcinogen involved in the pathogenesis of squamous cell carcinoma of the bladder. Cervical cancer incidence and mortality are highest in SSA, where pre-cancerous cervical dysplasia is often detected on screening with visual inspection with acetic acid (VIA). There are no studies evaluating the association between VIA positivity and FGS diagnosed by genital PCR.

Methods

Women were recruited from the Bilharzia and HIV (BILHIV) study in Zambia a community-based study comparing genital self-sampling to provider obtained cervicovaginal-lavage for the diagnosis of FGS in wom

SUBMITTER: Rafferty H 

PROVIDER: S-EPMC8286581 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature