Discovery of fibrillar adhesins across bacterial species.

ABSTRACT:

Background

Fibrillar adhesins are long multidomain proteins that form filamentous structures at the cell surface of bacteria. They are an important yet understudied class of proteins composed of adhesive and stalk domains that mediate interactions of bacteria with their environment. This study aims to characterize fibrillar adhesins in a wide range of bacterial phyla and to identify new fibrillar adhesin-like proteins to improve our understanding of host-bacteria interactions.

Results

Through careful literature and computational searches, we identified 82 stalk and 27 adhesive domain families in fibrillar adhesins. Based on the presence of these domains in the UniProt Reference Proteomes database, we identified and analysed 3,542 fibrillar adhesin-like proteins across specie

SUBMITTER: Monzon V 

PROVIDER: S-EPMC8286594 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature