Superoxide Oxidation by a Thiolate-Ligated Iron Complex and Anion Inhibition.

ABSTRACT: Superoxide (O₂^•-) is a toxic radical, generated via the adventitious reduction of dioxygen (O₂), which has been implicated in a number of human disease states. Nonheme iron enzymes, superoxide reductase (SOR) and superoxide dismutase (SOD), detoxify O₂^•- via reduction to afford H₂O₂ and disproportionation to afford O₂ and H₂O₂, respectively. The former contains a thiolate in the coordination sphere, which has been proposed to prevent O₂^•- oxidation to O₂. The work described herein shows that, in contrast to this, oxidized thiolate-ligated [Fe^III(S^Me2N₄(tren)(THF)]²⁺ (1^ox-THF

SUBMITTER: Dedushko MA 

PROVIDER: S-EPMC8286631 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature