Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis.

ABSTRACT:

Purpose

Uveitis is a heterogeneous collection of diseases. We tested the hypothesis that despite the diversity of uveitides, there could be common mechanisms shared by multiple subtypes, and that evidence of these common mechanisms may be detected as gene expression profiles in whole blood.

Design

Cohort study.

Methods

Ninety subjects with uveitis including axial spondyloarthritis (n = 17), sarcoidosis (n = 13), inflammatory bowel disease (n = 12), tubulointerstitial nephritis with uveitis (n = 10), or idiopathic uveitis (n = 38) as well as 18 healthy controls were enrolled, predominantly at Oregon Health & Science University. RNA-Seq data generated from peripheral, whole blood identified 19,859 unique transcripts. We analyzed gene expression pathways via Kyoto Encycl

SUBMITTER: Rosenbaum JT 

PROVIDER: S-EPMC8286715 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature