ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis.

ABSTRACT: The development of nanomedicines provides new opportunities for the treatment of atherosclerosis (AS) due to their great advantages such as the improved drug solubility, enhanced bioavailability and reduced side effects. Despite these advantages, nanomedicines are still facing some challenges. The problems remain in the short circulation life, lack of specific targeting and poor drug release controllability. In order to overcome the shortages of conventional nanomedicines, the combination of biomimetic strategy with smart nanoagents has been proposed. In light with the high reactive oxygen species (ROS) level in AS microenvironment and the fact that macrophages play a critical role in the pathogenesis of AS, we fabricated ROS-responsive biomimetic nanoparticles (NPs), which camouflaged mac

SUBMITTER: Tang D 

PROVIDER: S-EPMC8286794 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature