Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy.

ABSTRACT:

Aims

We aimed to assess sex-specific phenotypes and disease progression, and their relation to exercise, in arrhythmogenic cardiomyopathy (AC) patients.

Methods and results

In this longitudinal cohort study, we included consecutive patients with AC from a referral centre. We performed echocardiography at baseline and repeatedly during follow-up. Patients' exercise dose at inclusion was expressed as metabolic equivalents of task (MET)-h/week. Ventricular arrhythmia (VA) was defined as aborted cardiac arrest, sustained ventricular tachycardia, or appropriate therapy by implantable cardioverter-defibrillator. We included 190 AC patients (45% female, 51% probands, age 41 ± 17 years). Ventricular arrhythmia had occurred at inclusion or occurred during follow-up in 85 patients (33

SUBMITTER: Rootwelt-Norberg C 

PROVIDER: S-EPMC8286854 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature