Evaluation of the relationship between slow-waves of intracranial pressure, mean arterial pressure and brain tissue oxygen in TBI: a CENTER-TBI exploratory analysis.

ABSTRACT: Brain tissue oxygen (PbtO₂) monitoring in traumatic brain injury (TBI) has demonstrated strong associations with global outcome. Additionally, PbtO₂ signals have been used to derive indices thought to be associated with cerebrovascular reactivity in TBI. However, their true relationship to slow-wave vasogenic fluctuations associated with cerebral autoregulation remains unclear. The goal of this study was to investigate the relationship between slow-wave fluctuations of intracranial pressure (ICP), mean arterial pressure (MAP) and PbtO₂ over time. Using the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high resolution ICU sub-study cohort, we evaluated those patients with recorded high-frequency digital intr

SUBMITTER: Zeiler FA 

PROVIDER: S-EPMC8286934 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature