Assessment of liver fibrosis by transient elastography in young children with chronic hepatitis B virus infection.

ABSTRACT:

Background

This study aimed to compare the diagnostic accuracy of transient elastography (TE) and biopsy for the detection of liver fibrosis in children with chronic hepatitis B (CHB).

Methods

This single-center prospective study included 157 CHB children aged 0-6 years. All patients underwent liver stiffness measurement (LSM) by TE and liver biopsy, separated by an interval of less than 1 week.

Results

The LSM, aspartate aminotransferase-platelet ratio index (APRI), and fibrosis-4 index (FIB-4) were positively correlated with activity grade and fibrosis stage in CHB children. The areas under the receiver operating characteristic curves (AUCs) of LSM for identifying significant (F ≥ 2) and advanced (F ≥ 3) fibrosis were 0.732 and 0.941, respectively. The cut-off value

SUBMITTER: Xu Z 

PROVIDER: S-EPMC8286936 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature