4-step, 2-h carboplatin desensitization in Japanese patients with ovarian cancer: a prospective study.

ABSTRACT:

Background

Carboplatin is a key drug for ovarian cancer. However, it sometimes induces hypersensitivity reactions (HSRs) that result in the discontinuation of the treatment. Although various desensitization protocols have been reported in previous retrospective studies, a limited number of prospective studies have analyzed these protocols.

Methods

Patients with platinum-sensitive relapsed ovarian cancer who experienced carboplatin-induced HSRs were treated with diluted solutions of 1/1000, 1/100, 1/10 and an undiluted solution of carboplatin over a 1-h period. If no HSRs occurred within the first two cycles, a short protocol regimen over a 30-min period per solution was followed. The primary endpoint was treatment completion rate.

Results

Between May 2015 and Septembe

SUBMITTER: Nishimura M 

PROVIDER: S-EPMC8286943 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature