Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1.

ABSTRACT:

Objective

NAFLD is a complex disease marked by cellular abnormalities leading to NASH. NAFLD patients manifest low hepatic levels of CEACAM1, a promoter of insulin clearance. Consistently, Cc1^-/- null mice displayed spontaneous hyperinsulinemia/insulin resistance and steatohepatitis. Liver-specific reconstitution of Ceacam1 reversed these metabolic anomalies in 8-month-old Cc1^-/-xliver+ mice fed a regular chow diet. The current study examined whether it would also reverse progressive hepatic fibrosis in mice fed a high-fat (HF) diet.

Methods

3-Month-old mice were fed a high-fat diet for 3-5 months, and metabolic and histopathological analysis were conducted to evaluate their NASH phenotype.

Results

Reconstituting CEACAM1 to Cc1^-/- live

SUBMITTER: Helal RA 

PROVIDER: S-EPMC8286970 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature