Combining Device-Aided Therapies in Parkinson's Disease: A Case Series and a Literature Review.

ABSTRACT:

Background

Deep brain stimulation (DBS), levodopa-carbidopa intestinal gel (LCIG) and subcutaneous apomorphine infusion are device-aided therapies (DATs) for advanced Parkinson's disease (PD). We present a case series from the Cretan PD Registry who required 2 DATs for optimal management along with a systematic review of similar studies.

Cases

From 2009 to 2020, we retrospectively studied all PD patients who were simultaneously treated with 2 DATs. Six patients on DBS required an infusion treatment for persisting or re-emergent fluctuations because of disease progression. Two patients on LCIG infusion received DBS as a levodopa-sparing strategy because of drug-induced complications. Fluctuations and quality of life improved in all patients.

Literature review

We identi

SUBMITTER: Boura I 

PROVIDER: S-EPMC8287156 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature