Co-harboring of Novel bla _KPC-2 Plasmid and Integrative and Conjugative Element Carrying Tn6203 in Multidrug-Resistant Pseudomonas aeruginosa.

ABSTRACT: Many strains of the opportunistic pathogen Pseudomonas aeruginosa have acquired resistance to multiple antibiotics. Carbapenem-resistant P. aeruginosa poses a global healthcare problem due to limited therapeutic options for the treatment of infections. Plasmids and integrative and conjugative elements (ICEs) are the major vectors of antibiotic-resistance gene transfer. In our study, four carbapenem-resistant strains of P. aeruginosa were isolated from the same patient in a tertiary referral hospital in China, one of these was resistant to gentamicin and tobramycin. In this strain P33, we observed a non-transferable plasmid, pP33-2, carrying a novel bla _KPC-2 gene segment (ISKpn27-bla _KPC-2-ISKpn6-korC-ORF-klcA

SUBMITTER: Cai H 

PROVIDER: S-EPMC8287167 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature