FOLFIRINOX relative dose intensity and disease control in advanced pancreatic adenocarcinoma.

ABSTRACT:

Background

Most patients with advanced pancreatic adenocarcinoma (PA) treated with FOLFIRINOX experience adverse events requiring dose reduction. We aimed to assess the association between relative dose intensity (RDI) and disease control in a European setting.

Methods

We retrospectively included patients with advanced PA treated with three or more cycles of FOLFIRINOX between 2011 and 2018 in six French centers. We computed the cumulative single-agent RDI (csRDI) before the first reassessment for each FOLFIRINOX agent (oxaliplatin, irinotecan, 5FU bolus, and 5FU intravenous infusion) and the cumulative multi-drug RDI (cmRDI) of their combination. The association between RDI and disease control or objective response at first reassessment was evaluated using multivariable log

SUBMITTER: Vary A 

PROVIDER: S-EPMC8287268 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature