Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

ABSTRACT: Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged

SUBMITTER: Sakinah S 

PROVIDER: S-EPMC8287336 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature