Modifying Effects of Glucose and Insulin/Insulin-Like Growth Factors on Colon Cancer Cells.

ABSTRACT: There are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In the present study, we studied in vitro in human colorectal cancer cells originating from four Dukes' stages of colorectal cancer the effects of glucose, insulin and IGFs on proliferation, migration, cell cycle progression and gene expression of the IGF system. Growth of colon cancer cells originating from a Dukes' stage A was glucose-dependent, whereas growth of cancer cells from Dukes' stage B, C and D was glucose-independent. Stimulatory effects of insulin and IGFs on cell growth were observed only in colon cancer cells originating from Dukes' stage C and D. IGF-II stimulated migratio

SUBMITTER: Berk S 

PROVIDER: S-EPMC8287530 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature