A Catalog of Human Genes Associated With Pathozoospermia and Functional Characteristics of These Genes.

ABSTRACT: Genetic causes of the global decline in male fertility are among the hot spots of scientific research in reproductive genetics. The most common way to evaluate male fertility in clinical trials is to determine semen quality. Lower semen quality is very often accompanied by subfertility or infertility, occurs in many diseases and can be caused by many factors, including genetic ones. The following forms of lowered semen quality (pathozoospermia) are known: azoospermia, oligozoospermia, asthenozoospermia, teratozoospermia, and some combined forms. To systematize information about the genetic basis of impaired spermatogenesis, we created a catalog of human genes associated with lowered semen quality (HGAPat) and analyzed their functional characteristics. The catalog comprises data on 126 huma

SUBMITTER: Ignatieva EV 

PROVIDER: S-EPMC8287579 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature