CCR2 Deficiency Impairs Ly6C^lo and Ly6C^hi Monocyte Responses in Orientia tsutsugamushi Infection.

ABSTRACT: Orientia (O.) tsutsugamushi, the causative agent of scrub typhus, is a neglected, obligate intracellular bacterium that has a prominent tropism for monocytes and macrophages. Complications often involve the lung, where interstitial pneumonia is a typical finding. The severity of scrub typhus in humans has been linked to altered plasma concentrations of chemokines which are known to act as chemoattractants for myeloid cells. The trafficking and function of monocyte responses is critically regulated by interaction of the CC chemokine ligand 2 (CCL2) and its CC chemokine receptor CCR2. In a self-healing mouse model of intradermal infection with the human-pathogenic Karp strain of O. tsutsugamushi, we investigated the role of CCR2 on bacterial dissemination, development of sympto

SUBMITTER: Petermann M 

PROVIDER: S-EPMC8287586 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature