Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.

ABSTRACT:

Background

Tumor-infiltrating CD8⁺ T cells and neoantigens are predictors of a favorable prognosis and response to immunotherapy with checkpoint inhibitors in many types of adult cancer, but little is known about their role in pediatric malignancies. Here, we analyzed the prognostic strength of T cell-inflamed gene expression and neoantigen load in high-risk neuroblastoma. We also compared transcriptional programs in T cell-inflamed and non-T cell-inflamed high-risk neuroblastomas to investigate possible mechanisms of immune exclusion.

Methods

A defined T cell-inflamed gene expression signature was used to categorize high-risk neuroblastomas in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program (n=123), and the Gabriella Mill

SUBMITTER: Bao R 

PROVIDER: S-EPMC8287618 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature