Factors associated with response to neoadjuvant chemotherapy in advanced stage ovarian cancer.

ABSTRACT:

Objectives

To evaluate the factors associated with response to neoadjuvant chemotherapy (NACT) and the ability to undergo interval tumor reductive surgery (iTRS) in patients with advanced ovarian cancer.

Methods

We performed a retrospective review from April 2013 to March 2019 of patients with advanced stage ovarian cancer triaged to NACT based on our standard triage algorithm. Clinicopathologic and treatment data were analyzed for factors associated with response to NACT, outcomes at iTRS, and their impact on progression-free survival (PFS).

Results

562 patients met inclusion criteria and triaged to NACT following laparoscopy (n = 132) or without laparoscopy (n = 430). 413 patients underwent iTRS (74%). Factors that correlated with a patient reaching iTRS included in

SUBMITTER: Fleming ND 

PROVIDER: S-EPMC8287765 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature