Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study.

ABSTRACT: Activation of the complement system propagates neuroinflammation and brain damage early and chronically after traumatic brain injury (TBI). The complement system is complex and comprises more than 50 components, many of which remain to be characterized in the normal and injured brain. Moreover, complement therapeutic studies have focused on a limited number of histopathological outcomes, which while informative, do not assess the effect of complement inhibition on neuroprotection and inflammation in a comprehensive manner. Using high throughput gene expression technology (NanoString), we simultaneously analyzed complement gene expression profiles with other neuroinflammatory pathway genes at different time points after TBI. We additionally assessed the effects of complement inhibition on n

SUBMITTER: Toutonji A 

PROVIDER: S-EPMC8287781 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature