Growth rate-dependent flexural rigidity of microtubules influences pattern formation in collective motion.

ABSTRACT:

Background

Microtubules (MTs) are highly dynamic tubular cytoskeleton filaments that are essential for cellular morphology and intracellular transport. In vivo, the flexural rigidity of MTs can be dynamically regulated depending on their intracellular function. In the in vitro reconstructed MT-motor system, flexural rigidity affects MT gliding behaviors and trajectories. Despite the importance of flexural rigidity for both biological functions and in vitro applications, there is no clear interpretation of the regulation of MT flexural rigidity, and the results of many studies are contradictory. These discrepancies impede our understanding of the regulation of MT flexural rigidity, thereby challenging its precise manipulation.

Results

Here, plausible explanations for these di

SUBMITTER: Zhou H 

PROVIDER: S-EPMC8287809 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature