Duration of Bisphosphonate Drug Holidays and Associated Fracture Risk.

ABSTRACT:

Background

Discontinuation of bisphosphonates (BP) or a "drug holiday" after several years of treatment is increasingly common. However, the association of drug holiday duration with future fracture risk is unclear.

Objectives

We evaluated the rate of fracture in relation to various lengths of drug holidays among women receiving long-term BP therapy.

Research design

Observational cohort study using US Medicare data 2006-2016. Incidence rates (IRs) and Cox proportional hazards models were used to evaluate the rate and adjusted hazard ratios (aHRs) controlling for potential confounders.

Subjects

Women aged 65 years and above enrolled in fee-for-service Medicare who had been adherent (≥80%) to alendronate, risedronate, or zoledronate for ≥3 years.

Measures

SUBMITTER: Curtis JR 

PROVIDER: S-EPMC8287838 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature