Moderate Alcohol Intake Changes Visual Perception by Enhancing V1 Inhibitory Surround Interactions.

ABSTRACT: Moderate alcohol consumption is considered to enhance the cortical GABA-ergic inhibitory system and it also variously affects visual perception. However, little behavioral evidence indicates changes of visual perception due to V1 modulated by alcohol intoxication. In this study, we investigated this issue by using center-surround tilt illusion (TI) as a probe of V1 inhibitory interactions, by taking into account possible higher-order effects. Participants conducted TI measures under sober, moderate alcohol intoxication, and placebo states. We found alcohol significantly increased repulsive TI effect and weakened orientation discrimination performance, which is consistent with the increase of lateral inhibition between orientation sensitive V1 neurons caused by alcohol intoxication. We also

SUBMITTER: Wang H 

PROVIDER: S-EPMC8287857 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature