Unknown cytomegalovirus serostatus in primary immunodeficiency disorders: A new category of transplant recipients.

ABSTRACT:

Background

Cytomegalovirus (CMV) serostatus of recipient (R) and donor (D) influences hematopoietic stem cell transplant (HSCT) outcome. However, it is not a reliable indicator of CMV infection in primary immunodeficiency disorder (PIDD) recipients who are unable to make adequate antigen-specific immunoglobulin (Ig) or who receive intravenous Ig (IVIg) prior to testing.

Objective

Since no data exist on PIDD with unknown CMV serostatus, we aimed to evaluate the relationship between pre-HSCT recipient and donor serostatus and incidence of CMV infection in recipients with unknown serostatus.

Methods

A retrospective analysis of all pediatric PIDD HSCTs (2007-2018) was performed at University of California San Francisco. Recipients were separated into categories based on p

SUBMITTER: Forlanini F 

PROVIDER: S-EPMC8287897 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature