Ontology highlight
ABSTRACT:
SUBMITTER: Shainer I
PROVIDER: S-EPMC8287899 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Shainer Inbal I Michel Maximilian M Marquart Gregory D GD Bhandiwad Ashwin A AA Zmora Nilli N Ben-Moshe Livne Zohar Z Zohar Yonathan Y Hazak Adi A Mazon Yael Y Förster Dominique D Hollander-Cohen Lian L Cone Roger D RD Burgess Harold A HA Gothilf Yoav Y
Current biology : CB 20190606 12
Agouti-related protein (AgRP) is a hypothalamic regulator of food consumption in mammals. However, AgRP has also been detected in circulation, but a possible endocrine role has not been examined. Zebrafish possess two agrp genes: hypothalamically expressed agrp1, considered functionally equivalent to the single mammalian agrp, and agrp2, which is expressed in pre-optic neurons and uncharacterized pineal gland cells and whose function is not well understood. By ablation of AgRP1-expressing neuron ...[more]