Preimplantation loss of fertilized human ova: estimating the unobservable.

ABSTRACT:

Study question

What proportion of fertilized human ova are lost before implantation?

Summary answer

An estimated 40 to 50% of fertilized ova fail to implant.

What is known already

Preimplantation loss is not detectable with current technology. Published estimates of preimplantation loss range from 10 to 70%.

Study design, size, duration

We combine data from epidemiologic, demographic, laboratory and in vitro fertilization studies to construct an empirical framework for the estimation of preimplantation loss. This framework is summarized in a user-friendly Excel file included in supplement.

Participants/materials, setting, methods

We draw from multiple sources to generate plausible estimates of fecundability, sterility, transient anovulation, intercourse

SUBMITTER: Wilcox AJ 

PROVIDER: S-EPMC8287936 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature