The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months.

ABSTRACT:

Background

Common bean and cowpea contain about 25% protein and 25% fiber, and are recommended as complementary foods in sub-Saharan Africa.

Objective

The objective of this study was to determine if a daily legume supplement given to Malawian infants aged 6 to 12 mo alters the 16S configuration of the fecal microbiota as read out by amplicon sequence variants (ASVs).

Methods

This study was conducted within the context of a randomized, double-blind, controlled clinical trial to assess whether cowpea or common bean supplementation reduced intestinal permeability or increased linear growth. There were 2 village clusters in which the study was conducted. Fresh stool collections were flash frozen from 236 infants at ≤6 time points. The stools were sequenced using Earth Mic

SUBMITTER: Ordiz MI 

PROVIDER: S-EPMC8287943 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature