Koi sleepy disease as a pathophysiological and immunological consequence of a branchial infection of common carp with carp edema virus.

ABSTRACT: Gills of fish are involved in respiration, excretion and osmoregulation. Due to numerous interactions between these processes, branchial diseases have serious implications on fish health. Here, "koi sleepy disease" (KSD), caused by carp edema virus (CEV) infection was used to study physiological, immunological and metabolic consequences of a gill disease in fish. A metabolome analysis shows that the moderately hypoxic-tolerant carp can compensate the respiratory compromise related to this infection by various adaptations in their metabolism. Instead, the disease is accompanied by a massive disturbance of the osmotic balance with hyponatremia as low as 71.65 mmol L^-1, and an accumulation of ammonia in circulatory blood causing a hyperammonemia as high as 1123.24 µmol L^-1

SUBMITTER: Adamek M 

PROVIDER: S-EPMC8288041 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature