Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy.

ABSTRACT:

Purpose

Nonarteritic anterior ischemic optic neuropathy (NAION) is a common acute optic neuropathy in those older than 50 years. There is no blood diagnostic test or efficient treatment for NAION. We investigated the suitability of blood inflammatory proteins as biomarkers and therapeutic targets of NAION.

Methods

We conducted an exploratory, cross-sectional case-control study including 18 patients with NAION (n = 5 acute, and n = 13 chronic) and 9 controls. NAION was confirmed by clinical examination and optical coherence tomography. Subjects underwent peripheral blood collection; plasma was isolated within 2 hours and analyzed using a 76-plex array of cytokines, chemokines, and growth factors.

Results

In acute NAION, there was increased peripapillary retinal thickne

SUBMITTER: Mesentier-Louro LA 

PROVIDER: S-EPMC8288058 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature