Clinical Value and Underlying Mechanisms of Upregulated LINC00485 in Hepatocellular Carcinoma.

ABSTRACT:

Aims

This study aimed to reveal the functional role of LINC00485 in hepatocellular carcinoma (HCC).

Materials & methods

210 serum samples from Zhongnan Hospital of Wuhan University were employed to evaluate clinical value of LINC00485. Bioinformatics analysis was adopted to explore its potential mechanisms.

Results

LINC00485 was confirmed to be upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve revealed its prognostic and diagnostic roles. The combination of serum LINC00485 with AFP can remarkably improve diagnostic ability of HCC. Exploration of the underlying mechanism demonstrated that LINC00485 might exert pro-oncogenic activity by LINC00485-three miRNAs-four mRNAs n

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8288074 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature