Dataset Information

Initial Patterns of Prescription Opioid Supply and Risk of Mortality Among Insured Adults in the United States.

ABSTRACT:

Objective

To examine the association between initial patterns of prescription opioid supply (POS) and risk of all-cause mortality among an insured opioid-naïve patient population in the United States (US).

Methods

This retrospective observational cohort study used de-identified, administrative health care claims data from a large national insurer (Optum Clinformatics Data Mart) from 2010 to 2015. Participants included insured, cancer-free adults prescribed opioid analgesics. Prescription opioids received during the first 6 months of therapy were used to categorize initial patterns of POS as daily or nondaily. Cox regression was used to estimate the association of initial patterns of POS with all-cause mortality within one year of follow-up, adjusting for baseline covariates to control for confounding.

Results

A total of 4,054,417 patients were included, of which 2.75% had incident daily POS; 54.8% were female; median age was 50 years; mean Charlson comorbidity index (CCI) was 0.21 (standard deviation = 0.77); and mean daily morphine milligram equivalent was 34.61 (95% confidence intervals: 34.59, 34.63). There were 2068 more deaths per 100,000 person-years among patients who were prescribed opioids daily than nondaily. After adjusting for baseline covariates, the hazard of all-cause mortality among patients with incident daily POS was nearly twice that among those prescribed nondaily (hazard ratio [HR] = 1.94; 95% confidence intervals: 1.84, 2.04).

Conclusions

Among insured adult patients with noncancer pain, incident chronic POS was associated with a significantly increased risk of all-cause mortality over at most 1 year of follow-up. Because these results may be susceptible to bias, more research is needed to establish causality.

SUBMITTER: Aroke HA

PROVIDER: S-EPMC8288109 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Initial Patterns of Prescription Opioid Supply and Risk of Mortality Among Insured Adults in the United States.

Aroke Hilary A HA Buchanan Ashley L AL Bratberg Jeffrey J Hogan Joseph W JW Rich Josiah D JD Wen Xuerong X Kogut Stephen J SJ

Journal of addiction medicine 20210401 2

<h4>Objective</h4>To examine the association between initial patterns of prescription opioid supply (POS) and risk of all-cause mortality among an insured opioid-naïve patient population in the United States (US).<h4>Methods</h4>This retrospective observational cohort study used de-identified, administrative health care claims data from a large national insurer (Optum Clinformatics Data Mart) from 2010 to 2015. Participants included insured, cancer-free adults prescribed opioid analgesics. Presc ...[more]

PMID: 32769771

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Dataset Information

Initial Patterns of Prescription Opioid Supply and Risk of Mortality Among Insured Adults in the United States.

Objective

Methods

Results

Conclusions

Publications

Initial Patterns of Prescription Opioid Supply and Risk of Mortality Among Insured Adults in the United States.

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