Platelet-leukocyte aggregates - a predictor for acute kidney injury after cardiac surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) is one of the most common complications after cardiac surgery. However, effective biomarker used for early diagnosis of AKI has not been identified. Platelet-leukocyte aggregates (PLAs) participate in inflammation and coagulation, leading to vascular lesions and tissue destruction. We designed a prospective study to assess whether PLAs can serve as a good biomarker for early diagnosis of AKI after cardiac surgery.

Methods

Patients with rheumatic heart disease scheduled to undergo valve replacement surgery were enrolled. Blood samples were collected at five timepoints as follows: (a) At baseline. (b) At the end of extracorporeal circulation. (c) Arrival at intensive care unit (ICU). (d) Four-hours after the admission to ICU. (e) Twenty hou

SUBMITTER: Yang S 

PROVIDER: S-EPMC8288121 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature