Sequence- and structure-selective mRNA m⁵C methylation by NSUN6 in animals.

ABSTRACT: mRNA m⁵C, which has recently been implicated in the regulation of mRNA mobility, metabolism and translation, plays important regulatory roles in various biological events. Two types of m⁵C sites are found in mRNAs. Type I m⁵C sites, which contain a downstream G-rich triplet motif and are computationally predicted to be located at the 5^' end of putative hairpin structures, are methylated by NSUN2. Type II m⁵C sites contain a downstream UCCA motif and are computationally predicted to be located in the loops of putative hairpin structures. However, their biogenesis remains unknown. Here we identified NSUN6, a methyltransferase that is known to methylate C72 of tRNA^Thr and tRNA^Cys, as an mRNA methyltransferase that ta

SUBMITTER: Liu J 

PROVIDER: S-EPMC8288183 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature