Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial.

ABSTRACT:

Introduction

Glucose hypometabolism and insulin resistance increase risk for and accelerate progression in Parkinson's disease and neurocognitive disorders. We conducted a proof of concept trial to determine whether ketogenesis, a metabolic adaptation induced by dietary carbohydrate restriction, can improve cognitive performance in Parkinson's disease patients with mild cognitive impairment.

Methods

We enrolled patients with mild cognitive impairment associated with Parkinson's disease in an eight-week nutritional intervention with random assignment to either high-carbohydrate consumption typical of the Western dietary pattern (n = 7) or to a low-carbohydrate, ketogenic regimen (n = 7). We assessed changes in cognitive performance as well as motor function, ant

SUBMITTER: Krikorian R 

PROVIDER: S-EPMC8288565 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature