Ontology highlight
ABSTRACT:
SUBMITTER: Su W
PROVIDER: S-EPMC8289118 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Su Wenyue W Bi Xiaoning X Wang Yubin Y Baudry Michel M
BBA advances 20210213
Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs. Here, we identified 45 differentially expressed miRNAs (DE miRNAs) in the brain of calpain-1 KO mice, as compared to wild-type mice. In particular, among all the DE miRNAs, 7 neurodegeneration-related miRNAs were found to be down-regulated in calpain-1 KO mice. We also fou ...[more]